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Amantadine drug interactions

Store amantadine at room temperature away from moisture and heat. Drink plenty of fluids and dress lightly while in hot weather and when exercising. What should I avoid while taking amantadine Symmetrel? Deaths have been reported from overdose with amantadine hydrochloride. The lowest reported acute lethal dose was 1 gram. Acute toxicity may be attributable to the anticholinergic effects of amantadine. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. The usual dose of Symmetrel is 100 mg twice a day when used alone. Symmetrel has an onset of action usually within 48 hours.

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. But it can seriously interfere with daily life. People with bowel incontinence may avoid social activities for fear of embarrassment. Amantadine-resistant influenza A viruses also are resistant to rimantadine and vice versa. The most common cause of bowel is damage to the muscles around the anal sphincters. Vaginal can damage the anal sphincters or their nerves. That's why women are affected by accidental bowel leakage about twice as often as men.

What should i avoid while taking amantadine

The usual dose of Amantadine Hydrochloride Tablets is 100 mg twice a day when used alone. Amantadine Hydrochloride Tablets have an onset of action usually within 48 hours. When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well. Inform your doctor if your condition persists or worsens. Amantadine hydrochloride oral solution USP is available as a clear, fruit punch flavored oral solution containing 50 mg amantadine hydrochloride per 5 mL 1 teaspoonful. It is supplied in containers of 16 fl oz 473 mL.

This is used to treat MS

Drowsiness, dizziness, constipation, flushing, nausea, nervousness, blurred vision, or dry mouth may occur. These effects usually lessen as your body gets used to the medicine. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using amantadine hydrochloride tablets for any indication. The apparent oral plasma clearance of amantadine is reduced and the plasma half-life and plasma concentrations are increased in healthy elderly individuals age 60 and older.



Amantadine forms and strengths

Were you in a car accident? Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza. Symmetrel has not been shown to prevent such complications. If you are taking amantadine to treat influenza A, take the medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Degelau J, Somani S, Cooper SL, Irvine PW "Occurrence of adverse effects and high amantadine concentrations with influenza prophylaxis in the nursing home. Exercises. Begin a program of regularly contracting the muscles used to control urinary flow . This builds strength in the pelvic muscles and may help reduce bowel incontinence. The mechanism of action of amantadine hydrochloride in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. Data from earlier animal studies suggest that amantadine hydrochloride may have direct and indirect effects on dopamine neurons. It is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. Eight metabolites of amantadine have been identified in human urine. One metabolite, an N-acetylated compound, was quantified in human urine and accounted for 5 to 15% of the administered dose. Plasma acetylamantadine accounted for up to 80% of the concurrent amantadine plasma concentration in 5 of 12 healthy volunteers following the ingestion of a 200 mg dose of amantadine. Acetylamantadine was not detected in the plasma of the remaining seven volunteers. The contribution of this metabolite to efficacy or toxicity is not known. What is the key to flu influenza prevention? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Amanatadine is removed in negligible amounts by hemodialysis. Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine. Englund JA, Champlin RE, Wyde PR et al. Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. Clin Infect Dis.



What conditions does amantadine treat

People with Parkinson's disease may have a higher risk of skin cancer melanoma. Talk to your doctor about this risk and what skin symptoms to watch for. Acta Pharmacologica et Toxicologica, Nordic Pharmacological Society. Adjust dose based on renal function; some patients tolerate the drug better when it is given in 2 divided daily doses to avoid adverse neurologic reactions. Patients receiving amantadine hydrochloride who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important. If you are currently using the medication listed above, tell your doctor or pharmacist before starting amantadine. Many effective treatments can help people with bowel incontinence. The dose of anticholinergic drugs or of Symmetrel should be reduced if atropine-like effects appear when these drugs are used concurrently. Abrupt discontinuation may also precipitate delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression and slurred speech. What are flu influenza symptoms in adults and in children? Miscellaneous - neuroleptic malignant syndrome see allergic reactions including anaphylactic reactions, edema and and fever. People with Parkinson's disease may have an increased risk for developing skin cancer melanoma. If you are taking this drug to treat Parkinson's disease, tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams.



Consult your doctor before -feeding

Parkes JD et al. Controlled trial of amantadine hydrochloride in Parkinson's disease. Lancet. Amantadine is used to prevent or treat a certain type of flu influenza A. If you have been infected with the flu, this medication may help make your symptoms less severe and shorten the time it will take you to get better. Taking amantadine if you have been or will be exposed to the flu may help to prevent you from getting the flu. This medication is an antiviral that is believed to work by stopping growth of the flu virus. This medication is not a vaccine. To increase the chance that you will not get the flu, it is important to get a flu shot once a year at the beginning of every flu season, if possible. Maugh, T. 1979. "Panel urges wide use of antiviral drug". Science. Or are they slightly slanted? Overdose symptoms may include fever, aggression, behavior changes, hallucinations, severe headache or pounding in your ears, muscle stiffness, problems with balance or walking, fast heart rate, urinating less than usual, trouble breathing, seizure convulsion or fainting. What should I avoid while taking amantadine? Michalski LS, Hantsch Bardsley C, Holt DR, Milner JE, Hou SH "Altered mental status in a transplant patient. Amantadine toxicity. The adverse effects of amantadine are generally mild and, when they occur, may diminish or cease after a week or more on the medication. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.



Does amantadine interact with other medications

CDC and other experts recommend that adamantanes amantadine, rimantadine not be used for prevention of influenza in the US until susceptibility to these antiviral agents has been reestablished in circulating influenza A viruses. Have you had any other symptoms besides double vision? Highest Risk QTc-Prolonging Agents: QTc-Prolonging Agents Indeterminate Risk and Risk Modifying may enhance the QTc-prolonging effect of Highest Risk QTc-Prolonging Agents. Management: Avoid such combinations when possible. Use should be accompanied by close monitoring for evidence of QT prolongation or other alterations of cardiac rhythm. Care should be exercised when administering amantadine hydrochloride to patients with liver disease. Rare instances of reversible elevation of liver enzymes have been reported in patients receiving amantadine hydrochloride, though a specific relationship between the drug and such changes has not been established. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Fiore AE, Fry A, Shay D et al. Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices ACIP. MMWR Recomm Rep. The antiviral medicines and are used to prevent and treat A and B infections. Plasma concentrations in geriatric patients receiving a dosage of 100 mg daily approximate those attained in younger adults receiving a dosage of 200 mg daily. Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 1 gram. Because some patients have attempted suicide by overdosing with amantadine, prescriptions should be written for the smallest quantity consistent with good patient management.



Amantadine adult dosage

When amantadine and levodopa are started concurrently, rapid therapeutic benefits may occur. Amantadine dose should remain constant at 100 mg orally once or twice a day while the daily dose of levodopa is gradually increased to optimal benefit. If you take amantadine to treat influenza A, start taking the medicine within 24 to 48 hours after flu symptoms begin. Keep taking amantadine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Musculoskeletal side effects have included elevated creatine kinase during postmarketing experience. Seek medical attention immediately if it is suspected that an overdose of medication has been taken. Raiput, Amantadine-Dyazide Interaction, Can. Med. Assoc.



Jing X, Ma C, Ohigashi Y, et al 2008

How should I take Symmetrel amantadine? Substantially eliminated by the kidneys. 1 2 6 Consider age-related decreases in renal function and the potential for concomitant disease when selecting dosage. 1 2 6 See Geriatric Patients under Dosage and Administration. US Centers for Disease Control and Prevention. Information on avian influenza. From CDC website. Tell your doctor if your condition gets worse. Serious bacterial infections may present with influenza-like symptoms or may coexist with or occur as complications of influenza. 1 2 6 No evidence that amantadine prevents such complications. Symmetrel should resume normal activities gradually and cautiously, consistent with other medical considerations, such as the presence of osteoporosis or phlebothrombosis. Our Symmetrel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Sartori M, Pratt CM, Young JB. Torsade de pointe: malignant cardiac arrhythmia induced by amantadine poisoning. Am J Med. Interferon can make you more likely to get infections or may worsen any current infections. Symmetrel. Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Symmetrel. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges or other intense urges while taking Symmetrel. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking Symmetrel. SYMMETREL amantadine hydrochloride is indicated in the treatment of drug-induced extrapyramidal reactions. Although anticholinergic-type side effects have been noted with SYMMETREL amantadine hydrochloride when used in patients with drug-induced extrapyramidal reactions, there is a lower of these side effects than that observed with the anticholinergic antiparkinson drugs. Some patients who do not respond to anticholinergic antiparkinson drugs may respond to amantadine hydrochloride. When amantadine hydrochloride or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Amantadine is used to prevent or treat a certain type of flu A. If you have been infected with the flu, this medication may help make your symptoms less severe and shorten the time it will take you to get better. Taking amantadine if you have been or will be exposed to the flu may help to prevent you from getting the flu. This medication is an that is believed to work by stopping growth of the flu virus. This medication is not a vaccine. To increase the chance that you will not get the flu, it is important to get a once a year at the beginning of every flu season, if possible. The initial dose of SYMMETREL amantadine hydrochloride is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary.



What is amantadine

Wang C, Takeuchi K, Pinto LH, Lamb RA 1993. Watson Pharma Private Ltd. Parkes JD et al. Treatment of Parkinson's disease with amantadine and levodopa. Lancet. The concurrent use of amantadine with live attenuated influenza vaccine LAIV intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of amantadine, unless medically indicated. The concern about possible interference arises from the potential for antiviral drugs to inhibit replication of live vaccine virus. Trivalent inactivated influenza vaccine can be administered at any time relative to use of amantadine. Patients with a history of epilepsy or other seizure disorders should be observed closely for possible increased seizure activity. Seizures are not common in PD, and I do not think they are related to each other. However, a patient may have both of these conditions. I suspect it is very frustrating for you to not have a diagnosis. What medications treat the flu? Traumatic brain injury off-label use: Initial: 100 mg twice daily morning and afternoon; may increase total daily dose by 100 mg every week based on response and tolerability up to 200 mg twice daily. Additional data may be necessary to further define the role of amantadine in this condition Giacino 2012; Hammond 2014. Amantadine hydrochloride is well absorbed orally. Anorectal manometry. A pressure monitor is inserted into the anus and rectum. This allows measurement of the strength of the sphincter muscles. Parkinson disease developed syndrome of inappropriate antidiuretic hormone secretion nine days after starting amantadine and entacapone. The patient did not recover following discontinuation of entacapone. Five days after entacapone was stopped, amantadine was discontinued. The patient gradually improved following amantadine discontinuation. Simpson DM, Davis GC "Case report of neuroleptic malignant syndrome associated with withdrawal from amantadine. The adverse reactions reported most frequently at the recommended dose of Symmetrel 5-10% are: nausea, dizziness lightheadedness and insomnia. Inject this medication into a muscle as directed by your doctor, usually once a week. It is best to use this medication near to reduce side effects. May exacerbate mental problems in patients with a history of mental illness. Centers for Disease Control and Prevention CDC. Influenza activity--United States, 2012-13 season and composition of the 2013-14 influenza vaccine. MMWR Morb Mortal Wkly Rep.



Amantadine uses

Some patients who do not respond to anticholinergic antiparkinson drugs may respond to Amantadine Hydrochloride Capsules, USP. When Amantadine Hydrochloride Capsules, USP or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. How do health-care professionals diagnose the flu influenza? What is the incubation period for the flu? It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Care should be exercised when administering Symmetrel to patients with liver disease. Rare instances of reversible elevation of liver enzymes have been reported in patients receiving Symmetrel, though a specific relationship between the drug and such changes has not been established. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Kimberlin DW, Whitley RJ. Antiviral resistance: mechanisms, clinical significance, and future implications. J Antimicrob Chemother. Ing TS, Daugirdas JT, Soung LS, et al "Toxic effects of amantadine in patients with renal failure. Half-life prolonged in healthy geriatric adults. SYMMETREL amantadine hydrochloride is also indicated in the treatment of and drug-induced extrapyramidal reactions. Dosage can be increased to 300 mg daily in divided doses in patients with drug-induced extrapyramidal reactions. Neuroleptic malignant syndrome: Has been associated with neuroleptic malignant syndrome associated with dose reduction or abrupt discontinuation.



Side effects of amantadine

Amantadine Hydrochloride Tablets are not a substitute for early vaccination on an annual basis as recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices. Occasionally, patients whose responses are not optimal with Symmetrel at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians. Recommended viruses for influenza vaccines for use in the 2010-2011 northern hemisphere influenza season. Wkly Epidemiol Rec. How often did hospital staff describe possible side effects in a way you could understand? CPK, BUN, serum creatinine, alkaline phosphatase, LDH, bilirubin, GGT, SGOT, and SGPT. Chorea of Huntington disease off-label use: 100 mg 3 to 4 times daily. Additional data may be necessary to further define the role of amantadine in this condition Armstrong 2012; O'Suilleabhain 2003; Verhagen 2002. Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform. The initial dose of amantadine hydrochloride is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Influenza viruses change over time. Emergence of resistance mutations could decrease drug effectiveness. Other factors for example, changes in viral virulence might also diminish clinical benefit of antiviral drugs. Prescribers should consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use amantadine hydrochloride tablets. Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic H1N1 2009 Influenza, Bautista E, Chotpitayasunondh T et al. Clinical aspects of pandemic 2009 influenza A H1N1 virus infection. N Engl J Med. Ing TS et al. Accumulation of amantadine hydrochloride in renal insufficiency. N Engl J Med. Dose reduction or discontinuation of therapy has been reported to reverse these behaviors in some, but not all cases. Amantadine hydrochloride is excreted in human milk. Use is not recommended in nursing mothers. Schwab RS, England AC. Amantadine HCl Symmetrel and its relation to levodopa in the treatment of Parkinson's disease. Trans Am Neurol Assoc.



Indications and usage of amantadine

Centers for Disease Control and Prevention "Prevention and control of influenza: recommendations of the advisory committee on immunization practices ACIP. Committee on Infectious Disease. The management of NMS should include: 1 intense symptomatic treatment and medical monitoring, and 2 treatment of any concomitant serious medical problems for which specific treatments are available. Dopamine agonists, such as bromocriptine, and muscle relaxants, such as dantrolene are often used in the treatment of NMS, however, their effectiveness has not been demonstrated in controlled studies. But since most people who have the flu feel quite sick, some people may choose to take medicine even if they are at low risk for complications. Coadministration of quinine or quinidine with amantadine was shown to reduce the renal clearance of amantadine by about 30%. Symmetrel is indicated for chemoprophylaxis against signs and symptoms of influenza A virus infection. Because Symmetrel does not completely prevent the host immune response to influenza A infection, individuals who take this drug may still develop immune responses to natural disease or vaccination and may be protected when later exposed to antigenically related viruses. Following vaccination during an influenza A outbreak, Symmetrel prophylaxis should be considered for the 2- to 4-week time period required to develop an antibody response. Are the two objects side by side, or is one on top of the other? Gradually increase physical activity as the symptoms of Parkinson's disease improve. Patients receiving amantadine hydrochloride tablets who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important. Vale JA, Maclfan KS "Amantadine-induced heart-failure. This can provide information about the muscles and supporting structures in the anus, rectum, and pelvis.



Amantadine consumer information

Wilson TW, Rajput AH. Amantadine-dyazide interaction. Amantadine hydrochloride tablets are also indicated in the treatment of uncomplicated respiratory tract illness caused by influenza A virus strains especially when administered early in the course of illness. There are no well-controlled clinical studies demonstrating that treatment with amantadine hydrochloride tablets will avoid the development of influenza A virus pneumonitis or other complications in high risk patients. There is no clinical evidence indicating that amantadine hydrochloride tablets are effective in the prophylaxis or treatment of viral respiratory tract illnesses other than those caused by influenza A virus strains. Do not abruptly discontinue amantadine in patients with parkinsonian syndrome; some patients have developed parkinsonian crises after abrupt discontinuance of the drug. 1 2 6 Abrupt discontinuance also may precipitate delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, and slurred speech. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients. Store at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Salgado JC, Gutknecht DR "A reticular rash. Amantadine hydrochloride oral solution USP is contraindicated in patients with known hypersensitivity to amantadine hydrochloride or to any of the other ingredients in amantadine hydrochloride oral solution USP. Muzi F, Orlando G, Ielpo B, et al. "Amantadine monotherapy is ineffective in the treatment of hepatitis C virus recurrence in the post-liver transplantation setting. What happens if I miss a dose Symmetrel? The dose of amantadine hydrochloride may need careful adjustment in patients with congestive heart failure, peripheral edema, or orthostatic hypotension. Care should be exercised when administering amantadine hydrochloride to patients with a history of recurrent eczematoid rash, or to patients with psychosis or severe psychoneurosis not controlled by chemotherapeutic agents.



Amantadine warnings

Anon. Amantadine Symmetrel and rimantadine Flumadine . In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. Patients initially deriving benefit from Amantadine Hydrochloride Tablets not uncommonly experience a fall-off of effectiveness after a few months. Benefit may be regained by increasing the dose to 300 mg daily. Alternatively, temporary discontinuation of Amantadine Hydrochloride Tablets for several weeks, followed by reinitiation of the drug, may result in regaining benefit in some patients. A decision to use other antiparkinson drugs may be necessary. Centers for Disease Control and Prevention. Epidemiology and prevention of vaccine-preventable diseases. 12th ed. Washington DC: Public Health Foundation; 2012 May. Updates may be available at CDC website. Brands listed are trademarks of their respective owners. If you are taking amantadine for a viral infection, begin taking it as soon as possible. Continue taking it until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a relapse of the infection. May diminish the therapeutic effect of Anti-Parkinson Agents Dopamine Agonist. Management: Consider using an alternative antipsychotic agent when possible in patients with Parkinson disease. If an atypical antipsychotic is necessary, consider using clozapine or quetiapine, which may convey the lowest interaction risk. Acute toxicity may be attributable to the anticholinergic effects of amantadine. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress including adult respiratory distress syndrome - ARDS have been reported; renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, agitation, aggressive behavior, hypertonia, hyperkinesia, ataxia, gait abnormality, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucinations, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred. Neumayer EM et al. Antiviral activity of amantadine in tissue culture and in ovo. Proc Soc Exp Biol Med. The total daily dose is 200 mg given as one capsule of 100 mg twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. When Symmetrel and levodopa are initiated concurrently, the patient can exhibit rapid therapeutic benefits. Symmetrel should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit. Store in the refrigerator away from light. not freeze. This may also be stored at room temperature for up to 7 days. Keep all away from children and pets. Fatalities reported following overdosage. 1 2 6 Overdosage has resulted in cardiac arrhythmia, tachycardia, hypertension respiratory, renal, or CNS toxicity; may be related to anticholinergic effects of the drug. Are both images clear but not in line? Patient may experience nausea or insomnia. Have patient report immediately to prescriber behavioral changes, confusion, severe dizziness, passing out, hallucinations, seizures, shortness of breath, excessive weight gain, swelling of arms or legs, difficult urination, blurred vision, uncontrollable urges, change in balance, signs of depression suicidal ideation, anxiety, emotional instability, or confusion agitation, irritability, panic attacks, mood changes, skin growths, mole changes, or signs of neuroleptic malignant syndrome fever, muscle cramps or stiffness, dizziness, severe headache, confusion, change in thinking, tachycardia, abnormal heartbeat, or sweating a lot HCAHPS. If you take amantadine for Parkinson symptoms: You should not stop using amantadine suddenly or your condition may become worse.



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Important information


Braley, TJ; Chervin, RD Aug 2010

The initial dose of amantadine hydrochloride tablets is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Occasionally, patients whose responses are not optimal with amantadine hydrochloride tablets at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians. The adult daily dosage of Symmetrel is 200 mg; two 100 mg tablets or four teaspoonfuls of syrup as a single daily dose. The daily dosage may be split into one tablet of 100 mg or two teaspoonfuls of syrup twice a day. If central nervous system effects develop in once-a-day dosage, a split dosage schedule may reduce such complaints.

Were you in a car accident?

Nausea, 1 2 6 dizziness lightheadedness 1 2 6 49 insomnia. CDC and other experts recommend that adamantanes amantadine, rimantadine not be used for treatment or prevention of influenza in the US until susceptibility to these antiviral agents has been reestablished in circulating influenza A viruses. CDC found that 100% of seasonal H3N2 and 2009 pandemic flu samples tested have shown resistance to adamantanes. The CDC issued an alert to doctors to prescribe the and instead of amantadine and rimantadine for treatment of flu.

Highlights for amantadine

How effective is the flu vaccine? To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Gaudry SE, Sitar DS, Smyth DD et al. Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther. Do not share this medication with others. Colostomy. Surgery to redirect the colon through an opening created in the of the belly. Colostomy is only considered when bowel incontinence persists despite all other treatments.

What other drugs will affect amantadine

F. Protect capsules from moisture. How long is the flu contagious, and how long does the flu last? Patients receiving SYMMETREL amantadine hydrochloride who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important. Amantadine may also be used for purposes not listed in this medication guide. What is the most important information I should know about amantadine? Some people taking medicines for Parkinson's disease have developed skin cancer melanoma. However, people with Parkinson's disease may have a higher risk than most people for developing melanoma. Talk to your doctor about your specific risk and what skin symptoms to watch for. You may need to have regular skin exams.

At least one case of dropped head syndrome associated with unbalanced contraction of the neck muscles has been reported. Neuroleptic malignant syndrome, involuntary muscle contractions, coma, stupor, hypokinesia, hypertonia, gait abnormalities, paresthesia, EEG changes, and tremor have been reported during postmarketing experience. Agitation, hallucinations, stupor, and slurred speech have also occurred after abrupt discontinuation. Careful observation is required when amantadine hydrochloride is administered concurrently with central nervous system stimulants. H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990. Antimicrob Agents Chemother.

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